Lupron: Everything You Ever Wanted to Know!

You’ve made your decision to become a surrogate, you’ve passed screenings, matched, and come so far… and now this large box of medications was just delivered to your doorstep! Deep breaths honey, you’ve got this! We’re here to help, and will break it down medication by medication for you to fully process and understand what each one does.

In this post we will explain everything you’ve ever wanted to know about Lupron!

What is Lupron?

Lupron (leuprolide) is meant to overstimulate the body’s own production of certain hormones.  In doing so, Lupron causes that production to shut down temporarily. Lupron reduces the amount of estrogen in women, and (usually) causes ovulation to stop completely. 

However, you may still be able to get pregnant while on Lupron.  Because of this risk your RE will most likely have you restrict all sexual activities during this time. The purpose behind restricting sexual activities is to keep everything calm and quiet within your body as you are medically preparing your body for pregnancy.

If you are not on any restrictions (check with your doctor first!) please use a barrier form of birth control (condom or diaphragm with spermicide), as hormonal contraceptions (birth control pills, injections, implants, skin patches, and vaginal rings) may not be effective enough alone to prevent pregnancy during your treatment.

Take Note: 

Because Lupron/Leuprolide is expected to cause your menstrual periods to stop, contact your doctor if your periods continue while you are being treated with this medicine.

It is not known whether leuprolide passes into breast milk or if it could harm a nursing baby. You should not breast-feed while using this medicine.

Do NOT take Lupron if you are pregnant! If you become pregnant while on Lupron, notify your doctor right away.

How Do I Take Lupron?

Lupron is injected under the skin or into a muscle. You will be shown how to administer the injections at home by a nurse at your fertility clinic, as well as the dosage to take. If you have any questions or concerns with administering Lupron, give your clinic a call and they will be able to walk you through it.  We’ve created a photo tutorial on how to properly administer Lupron injections.

Lupron Tutorial

If you prefer a video tutorial, we’ve got you covered there as well!

Does Lupron Have Any Side Effects?

As with most medications, yes, lupron does have some side effects.  What, if any, side effects you experience is something that will vary from person to person.

Some common Lupron side effects may include:

  • mood changes, hot flashes, sweating, acne, rash, itching;
  • headache, joint pain, back pain, or general pain;
  • cold or flu symptoms, weakness, feeling tired, trouble breathing;
  • vaginal itching or discharge;
  • breakthrough bleeding in a female child during the first weeks of Lupron treatment;
  • swelling, bloating, weight gain, problems with urination;
  • decreased testicle size;
  • redness, burning, stinging, pain, swelling, or oozing where the shot was given.

Get emergency medical help if you have any of these signs of an allergic reaction to Lupron:

hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • bone pain, loss of movement in any part of your body;
  • swelling, rapid weight gain;
  • pain, burning, stinging, bruising, or redness where the medication was injected;
  • vomiting, confusion, slow heart rate, weak pulse, fainting, or slow breathing;
  • sudden chest pain or discomfort, wheezing, dry cough or hack;
  • painful or difficult urination;
  • increased thirst or urination, hunger, dry mouth, fruity breath odor, drowsiness, dry skin;
  • heart attack symptoms – chest pain or pressure, pain spreading to your jaw or shoulder, nausea, sweating; or
  • signs of a stroke – sudden numbness or weakness (especially on one side of the body), sudden severe headache, slurred speech, problems with vision or balance.

Rare but serious side effects may include:

  • pain or unusual sensations in your back, numbness, weakness, or tingly feeling in your legs or feet;
  • muscle weakness or loss of use, loss of bowel or bladder control; or
  • liver problems – nausea, upper stomach pain, itching, tired feeling, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

 If you have any concerns or questions with using Lupron, contact your doctor for further discussion.  This post is meant for informational purposes only. We are not doctors or medical professionals and will always advise you to speak with the RE in charge of your cycle.


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